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oAd + LP
- Development stage
- Preclinical
- Lead developer
- GeneMedicine
- Modality
- Oncolytic Viruses → Oncolytic Therapeutics, Viral-delivered RNAi → In Vivo RNAi → Gene Silencing → Gene Therapies, Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Intravenous
01
Overview
oAd + LP is an experimental therapeutic formulation consisting of an oncolytic adenovirus (oAd) encapsulated within a lipid envelope (liposome). In the specific research context provided, the oAd is engineered to co-express short-hairpin RNA (shRNA) against Wnt5 (shWnt5) and the proteoglycan decorin to enhance antitumor efficacy. The liposomal encapsulation (LP) is designed to protect the viral particles from systemic clearance and reduce non-specific accumulation in the liver, which are common limitations of systemic oncolytic virotherapy. While this formulation lacks the advanced pH-responsive and EGFR-targeting modifications of related variants (such as oAd/LP-GE-PS), it serves as a foundational delivery system that demonstrates improved safety profiles and attenuated hepatic toxicity compared to naked adenovirus in preclinical models of EGFR-positive breast cancer.
- Other names
- liposomal oncolytic adenovirusliposome-encapsulated oncolytic adenovirus
02
Targets
DCN (Decorin)WNT5A (Protein Wnt-5a)VLDL (Very low-density lipoprotein)
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