ocp + metformin

OCP + metformin refers to the combination therapy of a combined oral contraceptive pill (COCP or OCP) and the insulin-sensitizing agent metformin. This regimen is primarily used in the management of polycystic ovary syndrome (PCOS), targeting both hyperandrogenism and metabolic disturbances such as insulin resistance. Oral contraceptives act by suppressing ovarian androgen production through inhibition of gonadotropin secretion, while metformin improves insulin sensitivity by inhibiting hepatic gluconeogenesis and enhancing peripheral glucose uptake. The combination aims to address both hormonal imbalances (e.g., hirsutism, menstrual irregularity) and metabolic dysfunctions (e.g., impaired glucose tolerance) seen in PCOS. Clinical studies suggest that this combination may offer additional benefits over monotherapy for certain metabolic outcomes but with variable effects on weight, menstrual regulation, and androgen levels[1][2][5][7].

Other names

combined oral contraceptive pill + metforminCOCP + metforminOCP plus metformin