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ofloxacin + lactobacillus
- Development stage
- Unknown
- Lead developer
- AD Pharmaceuticals
- Modality
- Live Biotherapeutic Products → Microbiome Therapeutics, Small Molecules
- Administration
- Oral
01
Overview
Adof is a fixed-dose combination of the fluoroquinolone antibiotic ofloxacin and the probiotic Lactobacillus. It is used to treat various bacterial infections, including pneumonia, bronchitis, and urinary tract infections, while simultaneously preventing antibiotic-associated diarrhea. Ofloxacin acts by inhibiting bacterial DNA gyrase and topoisomerase IV, which are essential for DNA replication, transcription, and repair, thereby leading to bacterial cell death. Lactobacillus is a live probiotic microorganism that helps restore and maintain the natural balance of beneficial gut microflora, which is often disrupted by antibiotic therapy or intestinal infections.
- Brand names
- AdofFloxedMenflox LBOflabOflalak LBQxt-LBUneekVof LB
- Other names
- ofloxacin + lactobacillusofloxacin and lactobacillusofloxacin/lactobacillus
02
Targets
DNA gyraseTopo IV (Bacterial Topoisomerase IV)
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