ofloxacin + metronidazole

Ofloxacin + metronidazole is a fixed-dose combination medication containing two active pharmaceutical ingredients: ofloxacin (a fluoroquinolone antibiotic) and metronidazole (a nitroimidazole-class antiprotozoal and antibacterial agent). This combination is used to treat a variety of mixed bacterial and protozoal infections, particularly in the gastrointestinal tract (such as diarrhea and dysentery), genitourinary tract, respiratory system, skin/soft tissue infections, pelvic inflammatory disease, bacterial vaginosis, gynecological infections, dental abscesses/infections, intra-abdominal infections, and post-surgical infections[1][3][4][5]. - Ofloxacin acts by inhibiting bacterial DNA gyrase and topoisomerase IV enzymes involved in DNA replication—preventing cell division and leading to bactericidal activity against susceptible bacteria. - Metronidazole works by entering anaerobic bacteria/protozoa cells where it disrupts their DNA structure through reduction reactions—resulting in cell death. It is effective against anaerobic bacteria as well as protozoan parasites such as Entamoeba histolytica[1][4][5]. The combination provides broad-spectrum coverage for mixed aerobic-anaerobic or protozoal-bacterial infections. Both drugs are small molecules administered orally or via suspension formulations.

Brand names

Diof SuspensionNew Normetother regional or generic brands

Other names

ofloxacin with metronidazoleofloxacin and metronidazole