ofloxacin + rifampicin

Ofloxacin + rifampicin is an oral combination therapy consisting of two antibiotics—ofloxacin, a fluoroquinolone that inhibits bacterial DNA gyrase and topoisomerase IV, and rifampicin (also known as rifampin), which inhibits bacterial DNA-dependent RNA polymerase. This combination has been studied for the treatment of various infections including prosthetic joint infections caused by staphylococci[1], brucellosis[2], and is also referenced in the context of multidrug regimens for leprosy[5]. The rationale for combining these agents lies in their complementary mechanisms targeting different aspects of bacterial nucleic acid synthesis. Of note, there are pharmacokinetic interactions between these drugs that may affect efficacy or resistance development[3][9].

Other names

ofloxacin and rifampicinofloxacin plus rifampicinO+R