ofloxacin + roxithromycin

Ofloxacin + roxithromycin is a fixed-dose combination of two antibacterial agents used to treat a variety of bacterial infections. Ofloxacin is a synthetic fluoroquinolone antibiotic that inhibits bacterial DNA gyrase, thereby preventing DNA replication and leading to cell death. Roxithromycin is a macrolide antibiotic that binds to the 50S ribosomal subunit, inhibiting protein synthesis in susceptible bacteria. The combination may be used for respiratory tract infections, skin and soft tissue infections, genitourinary tract infections, and other conditions where both Gram-positive and Gram-negative coverage is desired. In vitro studies suggest potential additive or synergistic effects against certain pathogens when these drugs are combined[1][3]. Both agents are orally bioavailable small molecules.

Other names

ofloxacin and roxithromycinofloxacin plus roxithromycin