oleoylethanolamide + LipiSperse

Oleoylethanolamide + LipiSperse is a combination dietary supplement containing **oleoylethanolamide (OEA)**, a naturally occurring bioactive lipid mediator, and **LipiSperse**, a lipid-based dispersion delivery technology designed to enhance the oral bioavailability of lipophilic compounds. OEA acts as a peroxisome proliferator-activated receptor-alpha (PPAR-α) agonist, regulating food intake, satiety, lipid metabolism, and exhibiting antioxidant effects. LipiSperse improves the dispersibility and absorption of OEA in the gastrointestinal tract. This specific combination is primarily under investigation for metabolic benefits, such as modulating incretin hormone release (e.g., GLP-1 via GPR119 activation), changes in insulin, glucose, DPP-4, glucagon, and appetite-related endpoints. The combination has been studied in healthy volunteers and is being developed as a dietary supplement for potential use in weight management and metabolic health support[1][2][3][4][5][6][7].