olmesartan + amlodipine

Duopresinn is a fixed-dose combination of olmesartan medoxomil and amlodipine besylate used for the treatment of hypertension. Olmesartan is an angiotensin II receptor antagonist (ARB) that blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively binding to the AT1 receptor in vascular smooth muscle and the adrenal gland. Amlodipine is a dihydropyridine calcium channel blocker (CCB) that inhibits the transmembrane influx of calcium ions into vascular smooth muscle and cardiac muscle, resulting in peripheral arterial vasodilation and reduced peripheral vascular resistance. The combination of these two antihypertensive agents provides a synergistic effect in lowering blood pressure, often used when monotherapy is insufficient. It is distributed by INNventa Pharm as a branded generic product.

Brand names

DuopresinnAzorSevikar

Other names

olmesartan medoxomil + amlodipine besylateolmesartan/amlodipine