Drug intelligence / Profile preview

Olmesartan + indapamide

Development stage
Unknown
Lead developer
Daewoong Pharmaceutical
Modality
Small Molecules
Administration
Oral
01

Overview

Olmesartan + indapamide is a fixed-dose combination of two antihypertensive agents used primarily for the treatment of hypertension (high blood pressure). Olmesartan is an angiotensin II receptor blocker (ARB) that selectively blocks the binding of angiotensin II to the AT1 receptor in vascular smooth muscle, leading to vasodilation and reduced blood pressure. Indapamide is a thiazide-like diuretic that promotes renal excretion of sodium and water, reducing plasma volume and peripheral vascular resistance. The combination provides additive or synergistic effects in lowering blood pressure by targeting different physiological pathways[1][3][5]. This therapy helps reduce cardiovascular risk associated with chronic hypertension.

Brand names
Olmy-DOlmesat ID
Other names
olmesartan medoxomil + indapamide
02

Targets

AGTR1 (Angiotensin II Type-1 receptor)SLC12A3 (Thiazide-sensitive sodium-chloride cotransporter)

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