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omega-3 + nigella sativa oil + indian costus

Development stage
Preclinical
Lead developer
GSK
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

This is a combination dietary supplement containing three main ingredients: - **Omega-3 fatty acids** (commonly derived from fish oil or plant sources), which are well-established for their anti-inflammatory and cardioprotective effects. - **Nigella sativa oil** (also known as black seed oil), which contains thymoquinone as its primary bioactive component. Nigella sativa has demonstrated antioxidant, anti-inflammatory, immunomodulatory, anticarcinogenic properties and may support glucose homeostasis and lipid profile. It is traditionally used for a variety of conditions including metabolic syndrome risk factors[1][2][7]. - **Indian costus** (Saussurea costus) root or essential oil is used in traditional medicine systems such as Ayurveda and Unani. It contains chemicals that may have antiparasitic activity and can slow intestinal activity; it has been used for digestive issues but lacks robust clinical evidence[4][5]. The combination aims to leverage the synergistic effects of these components to support metabolic health (e.g., reducing HbA1c in patients with metabolic syndrome risk), gut health, immune function (notably upper respiratory tract complaints), stress response modulation via cortisol reduction, antioxidant defense, and possibly gastrointestinal protection[1][2]. The precise mechanism of action involves multiple pathways including anti-inflammatory signaling modulation by omega-3s and thymoquinone from Nigella sativa.

Other names
omega-3omega3omega 3nigella sativa oilblack seed oilIndian costusSaussurea costus
02

Targets

COXPPARG (Peroxisome proliferator-activated receptor gamma)

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