Drug intelligence / Profile preview

omega-3 fatty acids (Hospital San Juan de la Cruz)

Development stage
Phase 1
Lead developer
Hospital San Juan de la Cruz
Modality
Small Molecules
Administration
Oral
01

Overview

Omega-3 polyunsaturated fatty acids (W-3 PUFAs) are a class of essential fatty acids, primarily eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), known for their potent anti-inflammatory and lipid-lowering properties. In the PROTEICA clinical trial (NCT02708771) sponsored by Hospital San Juan de la Cruz, high-dose omega-3 (4 g daily) was evaluated as a pharmacological intervention for patients with acute heart failure (AHF) presenting with hypoalbuminemia and high inflammatory activity. The treatment aims to modulate systemic inflammatory pathways, potentially reducing C-reactive protein (CRP) levels and improving serum albumin concentrations, which are often suppressed during acute inflammatory states in heart failure patients.

Brand names
LovazaOmacor
Other names
W-3 PUFAsW3 PUFAsW 3 PUFAsomega-3 polyunsaturated fatty acidsomega3 polyunsaturated fatty acidsomega 3 polyunsaturated fatty acidsn-3 polyunsaturated fatty acidsn3 polyunsaturated fatty acidsn 3 polyunsaturated fatty acidsEPADHAeicosapentaenoic aciddocosahexaenoic acid
02

Targets

FFAR4 (Free fatty acid receptor 4)PPARA (Peroxisome proliferator-activated receptor alpha)

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