omega-3 fatty acids (Universitätsklinikum Greifswald)

Omega-3 fatty acids (University Medicine Greifswald) refers to a specific nutritional intervention using fish oil-based lipid emulsions in parenteral nutrition for the treatment of sepsis syndrome. Developed as part of clinical research at University Medicine Greifswald, this approach involves supplementing parenteral nutrition to achieve a specific omega-3 to omega-6 polyunsaturated fatty acid (PUFA) ratio (typically 1:2). The mechanism of action involves the incorporation of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) into cell membranes, where they compete with arachidonic acid. This competition shifts the production of lipid mediators from pro-inflammatory eicosanoids (such as prostaglandin E2 and leukotriene B4) to less potent or anti-inflammatory mediators (such as prostaglandin E3 and leukotriene B5), thereby modulating the systemic inflammatory response syndrome (SIRS) associated with sepsis and potentially improving clinical outcomes in critically ill patients.

Other names

fish oiln-3 polyunsaturated fatty acidsn3 polyunsaturated fatty acidsn 3 polyunsaturated fatty acidsn-3 PUFAn3 PUFAn 3 PUFAomega-3 polyunsaturated fatty acidsomega3 polyunsaturated fatty acidsomega 3 polyunsaturated fatty acids