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Drug intelligence / Profile preview
OMP-131R10 + FOLFIRI
- Development stage
- Phase 1
- Lead developer
- Mereo BioPharma
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
- Administration
- Intravenous
01
Overview
OMP-131R10 + FOLFIRI is a **combination investigational therapy** comprising OMP-131R10 (rosmantuzumab), a humanized monoclonal antibody targeting R-spondin 3 (RSPO3), and the FOLFIRI chemotherapy regimen (folinic acid, fluorouracil, irinotecan)[2][3][4][5][8]. OMP-131R10 inhibits the R-spondin–LGR pathway, a key regulator of the Wnt signaling involved in cancer stem cell renewal and tumor growth, with potential antineoplastic activity, particularly in metastatic colorectal cancer. FOLFIRI acts through cytotoxic mechanisms targeting rapidly dividing cells. This combination aims to enhance anti-tumor efficacy by attacking cancer cells both through conventional cytotoxic chemotherapy and targeted disruption of cancer stem cell/Wnt signaling pathways[2][3][4][5][8].
- Other names
- anti-RSPO3 antibody + FOLFIRIrosmantuzumab + FOLFIRI
02
Targets
RSPO3 (R-spondin 3)TS (Thymidylate synthase)TOP1 (DNA Topoisomerase I)
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