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OMP-21M18 + FOLFIRI

Development stage: Unknown
Lead developer: Mereo BioPharma
Modality: Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
Administration: Intravenous

Overview

OMP-21M18 + FOLFIRI is a combination regimen used in oncology clinical trials, particularly for metastatic colorectal cancer. - **OMP-21M18** (also known as Demcizumab) is a humanized monoclonal antibody that targets delta-like ligand 4 (DLL4), a key ligand in the Notch signaling pathway. Inhibition of DLL4 disrupts tumor angiogenesis and cancer stem cell activity, impairing tumor growth and reducing tumor-initiating cell frequency. - **FOLFIRI** is a widely used chemotherapy combination consisting of leucovorin calcium (folinic acid), fluorouracil, and irinotecan hydrochloride. Together, these drugs target cell proliferation and DNA synthesis via multiple cytotoxic mechanisms.

Other names: Demcizumab + FOLFIRI

Targets

TOP1 (DNA Topoisomerase I)TS (Thymidylate synthase)DLL4

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