Onabotulinumtoxina + hydrogel

OnabotulinumtoxinA is a purified form of botulinum toxin type A, a neurotoxic protein produced by Clostridium botulinum. It acts by inhibiting the release of acetylcholine at neuromuscular junctions, resulting in temporary muscle paralysis or relaxation. OnabotulinumtoxinA is widely used for both therapeutic and cosmetic indications including chronic migraine prevention, overactive bladder with urgency urinary incontinence, upper and lower limb spasticity, cervical dystonia (neck muscle spasms), blepharospasm (eyelid spasms), strabismus (crossed eyes), hyperhidrosis (excessive sweating), and reduction of facial wrinkles[2][3]. The combination "onabotulinumtoxina + hydrogel" refers to an investigational formulation where onabotulinumtoxinA is delivered via intravesical instillation using a hydrogel as the delivery vehicle rather than traditional intradetrusor injection. This approach aims to treat refractory overactive bladder with urgency urinary incontinence while reducing the invasiveness of administration. However, clinical trials have shown that this combination was well tolerated but did not demonstrate efficacy over placebo for this indication[4][5].

Brand names

BotoxMyoblocJeuveauDyston

Other names

botulinum toxin type AonabotulinumtoxinA + hydrogel admixture