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Drug intelligence / Profile preview
ongericimab + toripalimab + bevacizumab + FOLFOX
- Development stage
- Phase 2
- Lead developer
- Junshi Biosciences
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
- Administration
- Intravenous
01
Overview
This combination therapy is being evaluated in the Phase II ONTOP clinical trial for the treatment of advanced microsatellite stable (MSS) or proficient mismatch repair (pMMR) colorectal cancer. The regimen consists of **ongericimab** (JS002), a monoclonal antibody targeting PCSK9; **toripalimab** (JS001), a monoclonal antibody targeting the PD-1 receptor; **bevacizumab**, an anti-VEGF monoclonal antibody; and the **FOLFOX** chemotherapy regimen (oxaliplatin, calcium folinate, and 5-fluorouracil). The study, sponsored by Shanghai Pudong Hospital, investigates whether the addition of a PCSK9 inhibitor can overcome the typical resistance of MSS/pMMR colorectal tumors to immune checkpoint inhibitors by modulating the tumor microenvironment and enhancing MHC-I expression.
- Brand names
- Tuoyi
- Other names
- JS002 + JS001 + bevacizumab + FOLFOX
02
Targets
DNAPCSK9 (Proprotein convertase subtilisin/kexin type 9)PDCD1 (Programmed cell death protein 1 receptor)TS (Thymidylate synthase)VEGFA (Vascular endothelial growth factor A)
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