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opioid addiction vaccine + Advax
- Development stage
- Preclinical
- Lead developer
- Vaxine
- Modality
- Recombinant Proteins and Enzymes, Vaccines & Immunotherapeutics
01
Overview
The opioid addiction vaccine with Advax adjuvant is a preclinical-stage hapten-conjugate vaccine being developed by Vaxine Pty Ltd. for the treatment of opioid use disorder (OUD) and prevention of overdose. This vaccine platform utilizes Vaxine's proprietary Advax adjuvant, a delta inulin polysaccharide-based adjuvant, combined with opioid-based haptens conjugated to immunogenic carrier proteins. Its mechanism of action involves inducing high-titer antibodies that bind to opioid molecules in the peripheral circulation. This sequestration prevents the drugs from crossing the blood-brain barrier and entering the central nervous system, thereby reducing the euphoric and reinforcing effects of the opioids.
- Other names
- opioid vaccineAdvax adjuvanted hapten-conjugate vaccine
02
Targets
MOR (Mu opioid receptor)
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