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opioid-free anesthesia + TCI ELEVELD
- Development stage
- Unknown
- Lead developer
- G. Gennimatas General Hospital
- Modality
- Small Molecules
- Administration
- Intravenous
01
Overview
Opioid-free anesthesia + TCI ELEVELD is a multimodal anesthetic protocol designed to eliminate the use of intraoperative opioids. This regimen typically utilizes a combination of non-opioid adjuncts such as ketamine, lidocaine, dexmedetomidine, and magnesium to provide analgesia and autonomic stability. The protocol is delivered via Total Intravenous Anesthesia (TIVA) using Target-Controlled Infusion (TCI) based on the Eleveld pharmacokinetic/pharmacodynamic (PK/PD) model. The Eleveld model is a versatile population model developed to optimize propofol dosing across diverse patient populations, including those with high body mass index (BMI). This specific protocol is being evaluated in clinical trials, such as those at G. Gennimatas General Hospital, for its impact on perioperative stress responses in patients undergoing bariatric surgery for obesity.
- Other names
- OFA + TCI ELEVELDOpioid-Free Anesthesia with Eleveld Model TCITIVA TCI ELEVELD Model
02
Targets
ADRA2A (α2A)GABRR (GABA-A receptor subunit rho)NMDAR (Glutamate receptor ionotropic, NMDA)NaV (Voltage-gated sodium channels)
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