Drug intelligence / Profile preview

Oraqix (lidocaine + prilocaine)

Development stage
Approved
Lead developer
Dentsply Sirona
Modality
Small Molecules
Administration
Topical
01

Overview

Oraqix is a needle-free, subgingival local anesthetic gel composed of a eutectic mixture of lidocaine and prilocaine (2.5%/2.5%). It is specifically indicated for use in adults requiring localized anesthesia in periodontal pockets during scaling and/or root planing procedures. The product features a unique thermosetting delivery system, existing as a low-viscosity liquid at room temperature and transforming into a gel at body temperature to ensure retention within the periodontal pocket. Its mechanism of action involves the reversible blockade of voltage-gated sodium channels in the neuronal membrane, which prevents the initiation and conduction of nerve impulses, thereby providing effective analgesia without the need for injections.

Brand names
Oraqix
Other names
lidocaine and prilocaine periodontal gel
02

Targets

NaV (Voltage-gated sodium channels)

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