orlistat + metformin

This entry refers to a clinical trial comparison between **orlistat** and **metformin** conducted by the Sheffield Teaching Hospitals NHS Foundation Trust. Orlistat is a gastrointestinal lipase inhibitor used for weight management by preventing the absorption of dietary fats. Metformin is a biguanide antihyperglycemic agent that improves insulin sensitivity and is frequently used off-label to treat polycystic ovary syndrome (PCOS) and related anovulation. The study specifically investigates the efficacy of these two agents in inducing weight loss and restoring ovulation in obese women who are experiencing anovulatory infertility. While both drugs are well-established in their respective primary indications, this trial (NCT00406133) aimed to determine the optimum management strategy for reproductive dysfunction in the context of obesity.

Brand names

XenicalAlliGlucophageFortametGlumetzaRiomet

Other names

Orlistat Vs MetforminMetformin Versus Orlistat