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Drug intelligence / Profile preview
Oxaliplatin + Fluorouracil + Leucovorin + Bevacizumab
- Development stage
- Phase 4
- Lead developer
- Sanofi
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
- Administration
- Intravenous
01
Overview
This regimen is a combination chemotherapy protocol used primarily for the treatment of metastatic colorectal cancer. It consists of four drugs: oxaliplatin (a platinum-based cytotoxic agent), fluorouracil (5-FU, an antimetabolite that inhibits DNA synthesis), leucovorin (folinic acid, which enhances the effect of fluorouracil), and bevacizumab (a monoclonal antibody targeting vascular endothelial growth factor A to inhibit angiogenesis). The combination works by interfering with cancer cell division and growth while also blocking the formation of new blood vessels that supply tumors. This regimen is typically administered intravenously in cycles every two weeks and has been shown to improve survival outcomes in patients with metastatic colorectal cancer[1][4][5][6][7].
- Other names
- FOLFOX-bevacizumabmFOLFOX6+BEVAGIFFOXB
02
Targets
DNATS (Thymidylate synthase)VEGFA (Vascular endothelial growth factor A)TUBB (Tubulin (alpha and beta subunits))
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