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oxaliplatin + fluorouracil + leucovorin + bevacizumab (University of Texas MD Anderson Cancer Center)
- Development stage
- Unknown
- Lead developer
- University of Texas MD Anderson Cancer Center
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
- Administration
- Intravenous, Intra-arterial
01
Overview
This combination therapy regimen, developed and evaluated by the M.D. Anderson Cancer Center, involves the administration of oxaliplatin via hepatic arterial infusion (HAI) in conjunction with systemic intravenous fluorouracil (5-FU), leucovorin, and bevacizumab (Avastin). The regimen is specifically designed for patients with advanced solid tumors that have metastasized to the liver. Oxaliplatin, a platinum-based small molecule, functions by forming DNA cross-links, thereby inhibiting DNA replication and transcription. Fluorouracil is a pyrimidine analog that inhibits thymidylate synthase, a key enzyme in DNA synthesis, while leucovorin is administered to enhance the binding and inhibitory effect of 5-FU on its target. Bevacizumab is a recombinant humanized monoclonal antibody that targets vascular endothelial growth factor (VEGF), inhibiting tumor angiogenesis. The use of HAI for oxaliplatin delivery aims to achieve high local drug concentrations within the liver while minimizing systemic side effects.
- Brand names
- AvastinEloxatin
- Other names
- HAI oxaliplatin + systemic 5-FU/LV/BevacizumabHepatic Arterial Infusion of Oxaliplatin + 5-FU/Leucovorin/Avastin
02
Targets
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