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oxaliplatin + leucovorin + fluorouracil + sintilimab + IBI305
- Development stage
- Unknown
- Lead developer
- Union Hospital of Huazhong University of Science and Technology
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
- Administration
- Intravenous, Intra-arterial
01
Overview
This triple therapy regimen combines hepatic arterial infusion chemotherapy (HAIC) using the FOLFOX protocol (oxaliplatin, leucovorin, and fluorouracil) with systemic administration of the PD-1 inhibitor sintilimab and the bevacizumab biosimilar IBI305. Developed and studied at Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, this approach is designed for the first-line treatment of advanced (BCLC-C) unresectable hepatocellular carcinoma. The regimen leverages the high local drug concentration of HAIC to achieve tumor debulking and potential surgical conversion, while systemic sintilimab and IBI305 provide synergistic immune checkpoint blockade and anti-angiogenic effects to control extrahepatic spread and enhance the local therapeutic response.
- Brand names
- TyvytByvasda
- Other names
- HAIC-Union Hospital, Tongji Medical College, Huazhong University of Science and Technology-hepatocellular carcinomaFOLFOX-HAIC + sintilimab + bevacizumab biosimilarHAIC-FOLFOX + sintilimab + IBI305HAIC + sintilimab + bevacizumabFOLFOXHAIC
02
Targets
VEGFA (Vascular endothelial growth factor A)TS (Thymidylate synthase)DNAPDCD1 (Programmed cell death protein 1 receptor)
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