oxycodone + morphine sulfate

This intervention refers to a clinical trial conducted at Brigham and Women's Hospital investigating the combination use of oxycodone and sustained-release morphine sulfate for the treatment of chronic low back pain. Oxycodone is a semi-synthetic opioid agonist, and morphine sulfate is a natural opioid alkaloid; both exert their analgesic effects primarily by binding to mu-opioid receptors in the central nervous system. The study was designed as a phase 1, double-blind, randomized controlled trial to evaluate changes in pain sensitivity and pain modulation (such as opioid-induced hyperalgesia) resulting from long-term oral opioid therapy. The protocol involved titrated doses of these well-established analgesics to assess individual differences in treatment outcomes and facilitate the tailoring of analgesic regimens for patients with chronic pain.

Other names

oxycodone + morphine sulfate-Brigham and Women's Hospital-chronic low back painSensory Effects of Oral Opioid Treatment in Patients With Chronic Low Back Pain