oxycodone + paracetamol (Molteni Farmaceutici)

Depalgos is a fixed-dose combination small molecule analgesic drug containing oxycodone hydrochloride, a semi-synthetic mu-opioid receptor agonist, and paracetamol (acetaminophen), a non-opioid analgesic. It is primarily indicated for the management of moderate to severe acute pain, particularly in the postoperative setting following orthopedic or general surgery. Oxycodone acts as an agonist at mu-opioid receptors in the central nervous system, altering the perception of and emotional response to pain. Paracetamol provides complementary analgesia, likely through the inhibition of prostaglandin synthesis in the central nervous system. Marketed in Italy by Molteni Farmaceutici, Depalgos is available in multiple strengths as film-coated and effervescent tablets, providing a synergistic approach to pain control by combining opioid and non-opioid mechanisms.

Brand names

Depalgos

Other names

oxycodone + acetaminophen