Drug intelligence / Profile preview

oxycodone + pregabalin

Development stage
Unknown
Lead developer
Pfizer
Modality
Small Molecules
Administration
Oral
01

Overview

Oxycodone + pregabalin is a combination medication used for the treatment of neuropathic pain, particularly in cancer patients and those with chronic pain conditions. This combination leverages the complementary mechanisms of action of both drugs to provide enhanced pain relief. Oxycodone is an opioid analgesic that acts on the central nervous system by binding to mu opioid receptors, while pregabalin is an anticonvulsant that decreases pain signals from damaged nerves. Studies show this combination provides more effective pain relief than either drug alone and allows for dose reduction of both agents compared to monotherapy.

Other names
oxycodone and pregabalin
02

Targets

DOR (Opioid Receptor Delta 1)KOR (Kappa opioid receptor)MOR (Mu opioid receptor)CACNA2D1 (Voltage-gated calcium channel subunit alpha2/delta-1)CACNA2D2 (α2δ-2)

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