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oxytetracycline + hydrocortisone
- Development stage
- Unknown
- Lead developer
- Pfizer
- Modality
- Small Molecules
- Administration
- Topical, Intranasal, Otic, Ophthalmic
01
Overview
Terracortril is a combination pharmaceutical product containing the broad-spectrum tetracycline antibiotic oxytetracycline and the mild corticosteroid hydrocortisone. Oxytetracycline exerts its antibacterial effect by binding to the 30S ribosomal subunit, thereby inhibiting bacterial protein synthesis. Hydrocortisone acts as a glucocorticoid receptor agonist to reduce inflammation, edema, and pruritus. This combination is primarily indicated for steroid-responsive inflammatory skin or mucosal conditions where a secondary bacterial infection is present or likely. In clinical research, it has been evaluated as a soaking agent for nasal packing following functional endoscopic sinus surgery (FESS) in patients with chronic rhinosinusitis with nasal polyps to improve healing and reduce postoperative inflammation.
- Brand names
- Terra-CortrilTerracortril
- Other names
- oxytetracycline and hydrocortisone
02
Targets
Mitoribosome (Mitochondrial ribosome)GR (Glucocorticoid receptor)30S A-site (Bacterial ribosomal 30S A-site)MR (Mineralocorticoid receptor)
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