Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
p1-(5'-adenosyl)p5-(5'-thymidyl)pentaphosphate
- Development stage
- Unknown
- Modality
- Small Molecules
01
Overview
p1-(5'-adenosyl)p5-(5'-thymidyl)pentaphosphate is a synthetic dinucleotide analog in which adenosine and thymidine are connected via a pentaphosphate bridge through their 5' positions. It is an experimental small molecule designed as a bisubstrate inhibitor of thymidylate kinase (TMPK), an enzyme involved in nucleotide metabolism. Structural studies have shown that it binds to the active site of TMPK and can serve as a tool compound for probing enzyme mechanism or for structure-based drug design targeting TMPK—an essential enzyme in DNA synthesis pathways of bacteria such as Mycobacterium tuberculosis[7]. The compound has not been approved for clinical use and is primarily used in biochemical research[2][7].
- Other names
- p1-(5'-adenosyl)p5-(5'-thymidyl)pentaphosphate[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl [hydroxy-[hydroxy-[hydroxy-[[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy]phosphoryl]oxyphosphoryl]oxyphosphoryl] hydrogen phosphate
02
Targets
TMPK (Thymidine monophosphate kinase (Mycobacterium tuberculosis))
Beyond the preview
Go deeper on p1-(5'-adenosyl)p5-(5'-thymidyl)pentaphosphate.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on p1-(5'-adenosyl)p5-(5'-thymidyl)pentaphosphate.