Clinical trials
Full profile accessFollow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
P22CYP-PpIX-PEG(EST)
- Development stage
- Preclinical
- Lead developer
- Universidad Nacional Autónoma de México
- Modality
- Split/Subunit Vaccines → Inactivated Vaccines → Prophylactic Vaccines → Vaccines & Immunotherapeutics, Cancer Vaccines → Therapeutic Vaccines → Vaccines & Immunotherapeutics, Recombinant Protein Vaccines → Recombinant Vaccines → Prophylactic Vaccines → Vaccines & Immunotherapeutics, Nanoparticles → Drug Delivery Systems
- Administration
- Parenteral
01
Overview
**P22CYP-PpIX-PEG(EST)** is a preclinical multifunctional biocatalytic nanoparticle for **estrogen receptor-positive breast cancer**. It comprises a bacteriophage P22 virus-like-particle nanocage encapsulating cytochrome P450 activity, surface-conjugated protoporphyrin IX for UV365 nm-triggered photodynamic generation of reactive oxygen species, and a PEG-linked estradiol-derived ligand to promote estrogen receptor-mediated uptake by ER-positive tumor cells. In vitro, the platform increased intracellular CYP activity and enhanced tamoxifen sensitivity through combined enzyme-mediated prodrug activation and photodynamic cytotoxicity. It is an academic research construct rather than an approved or clinically developed drug product. ([europepmc.org](https://europepmc.org/article/PMC/5819296))
- Other names
- P22CYP-PpIX-PEG (EST)P22CYP-PpIX-PEG(EST)
02
Targets
Cyp (Cyclophilin family)ESR1 (ERα)
Beyond the preview
Go deeper on P22CYP-PpIX-PEG(EST).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Full profile accessExplore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Full profile accessTrace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Full profile accessExplore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Full profile accessCompare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Full profile accessConnect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on P22CYP-PpIX-PEG(EST).