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Drug intelligence / Profile preview
paclitaxel + carboplatin + bevacizumab + erlotinib
- Development stage
- Phase 2
- Lead developer
- Bristol Myers Squibb
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
- Administration
- Intravenous, Oral
01
Overview
This is a four-drug combination regimen consisting of paclitaxel, carboplatin, bevacizumab, and erlotinib. Paclitaxel is a microtubule inhibitor that disrupts cell division; carboplatin is a platinum-based chemotherapeutic agent that causes DNA crosslinking; bevacizumab is a monoclonal antibody targeting vascular endothelial growth factor (VEGF), inhibiting angiogenesis; and erlotinib is an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor that blocks EGFR signaling pathways. This combination has been studied in phase II clinical trials for the treatment of carcinoma of unknown primary (CUP), particularly in patients with adenocarcinoma or poorly differentiated carcinoma who have not received prior therapy[1][4]. The regimen aims to combine cytotoxic chemotherapy with targeted therapies to improve response rates.
- Other names
- paclitaxel and carboplatin and bevacizumab and erlotinib
02
Targets
TUBB (Tubulin (alpha and beta subunits))VEGFA (Vascular endothelial growth factor A)Pt-DNA adduct (DNA-oxaliplatin adduct)EGFR (Epidermal growth factor receptor)
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