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paclitaxel + cisplatin + 5-fluorouracil
- Development stage
- Unknown
- Lead developer
- Bristol Myers Squibb
- Modality
- Small Molecules
- Administration
- Intravenous
01
Overview
A combination chemotherapy regimen consisting of paclitaxel, cisplatin, and 5-fluorouracil. This regimen has shown significant activity in treating locally advanced squamous cell carcinoma of the head and neck (SCCHN) and advanced gastric carcinoma. It works through multiple mechanisms including microtubule stabilization, DNA damage, and thymidylate synthase inhibition.
- Brand names
- TaxolPlatinolAdrucil
- Other names
- PPF
02
Targets
TUBB (Tubulin (alpha and beta subunits))DNATS (Thymidylate synthase)
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