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paclitaxel + estramustine + carboplatin
- Development stage
- Phase 2
- Lead developer
- SCRI Development Innovations
- Modality
- Small Molecules
- Administration
- Intravenous, Oral
01
Overview
This combination chemotherapy regimen, consisting of paclitaxel, estramustine, and carboplatin, was evaluated by SCRI Development Innovations, LLC for the treatment of castration-resistant prostate cancer (CRPC), also known as hormone-refractory prostate cancer. Paclitaxel is a taxane that stabilizes microtubules, preventing cell division and inducing apoptosis. Estramustine is a conjugate of estradiol and nitrogen mustard that interferes with microtubule dynamics by binding to microtubule-associated proteins (MAPs). Carboplatin is a platinum-based antineoplastic agent that induces DNA cross-linking, inhibiting DNA synthesis and transcription. The regimen was specifically investigated in a Phase II trial to optimize the dosing and schedule of carboplatin when administered alongside weekly paclitaxel and low-dose estramustine to improve efficacy and reduce toxicity in advanced prostate cancer patients.
- Other names
- Weekly Paclitaxel, Estramustine, and CarboplatinTEC regimenPaclitaxel, Estramustine, and Carboplatin
02
Targets
DNAER (Estrogen receptor)APC (Activated protein C)TUBB (Tubulin (alpha and beta subunits))
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