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paclitaxel + pemetrexed
- Development stage
- Unknown
- Modality
- Small Molecules
- Administration
- Intravenous
01
Overview
A chemotherapy combination regimen consisting of paclitaxel and pemetrexed. Both drugs are cytotoxic agents with different mechanisms of action. This combination has been studied in various solid tumors including non-small cell lung cancer (NSCLC), thyroid carcinoma, and mesothelioma. Clinical trials have evaluated different dosing schedules to determine the maximum tolerated dose, safety profile, and preliminary efficacy.
- Brand names
- AlimtaPemfexyPemrydi RtuTaxolOnxolAbraxane
- Other names
- none
02
Targets
DHFR (Dihydrofolate reductase)TUBB (Tubulin (alpha and beta subunits))GART (GAR transformylase)TS (Thymidylate synthase)
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