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paclitaxel + raltitrexed
- Development stage
- Unknown
- Lead developer
- Fudan University
- Modality
- Small Molecules
- Administration
- Intravenous
01
Overview
Paclitaxel + raltitrexed is an investigational combination chemotherapy regimen. Paclitaxel is a taxane that stabilizes microtubules, thereby inhibiting cell division. Raltitrexed is a quinazoline folate analogue that acts as a potent, specific inhibitor of thymidylate synthase (TS), leading to DNA fragmentation and cell death. This combination has been primarily studied by Fudan University Shanghai Cancer Center as a second-line treatment for advanced or metastatic gastric cancer and gastroesophageal junction adenocarcinoma. A Phase II trial (NCT02072317) compared this combination to paclitaxel monotherapy, showing potential improvements in progression-free and overall survival, although the results were not statistically significant.
- Other names
- taxel + raltitrexedPaclitaxel Plus Raltitrexed Plug
02
Targets
TUBB (Tubulin (alpha and beta subunits))TS (Thymidylate synthase)
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