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Drug intelligence / Profile preview
paclitaxel + topotecan + filgrastim
- Development stage
- Phase 2
- Lead developer
- University of Texas MD Anderson Cancer Center
- Modality
- Small Molecules, Recombinant Proteins and Enzymes
- Administration
- Intravenous, Subcutaneous
01
Overview
This combination chemotherapy regimen was evaluated in a Phase II clinical trial conducted at M.D. Anderson Cancer Center for the treatment of relapsed and refractory aggressive non-Hodgkin's lymphoma (NHL). The regimen consists of **paclitaxel**, a microtubule-stabilizing agent that arrests the cell cycle in the G2/M phase; **topotecan**, a topoisomerase I inhibitor that induces lethal DNA double-strand breaks during replication; and **filgrastim-SD/01**, a granulocyte colony-stimulating factor (G-CSF) used as supportive care to accelerate neutrophil recovery following intensive chemotherapy. This salvage therapy was specifically developed for patients who had previously failed standard anthracycline- or platinum-based chemotherapy regimens.
- Other names
- Paclitaxel and Topotecan with Filgrastim-SD/01 supportPaclitaxel and Topotecan with Filgrastim-SD/01 in Aggressive NHL
02
Targets
TUBB (Tubulin (alpha and beta subunits))CSF3R (Granulocyte colony-stimulating factor receptor)TOP1 (DNA Topoisomerase I)
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