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paclitaxel polymer micelles + gemcitabine + anlotinib
- Development stage
- Unknown
- Lead developer
- Shanghai Sixth People’s Hospital
- Modality
- Nanoparticles → Drug Delivery Systems, Small Molecules
- Administration
- Intravenous, Oral
01
Overview
This combination therapy regimen consists of paclitaxel polymer micelles, gemcitabine, and anlotinib. Paclitaxel polymer micelles is a nanoparticle formulation of the taxane paclitaxel designed to improve solubility and reduce hypersensitivity reactions by avoiding Cremophor EL. Gemcitabine is a pyrimidine nucleoside analog that inhibits DNA synthesis. Anlotinib is a multi-targeted tyrosine kinase inhibitor that inhibits vascular endothelial growth factor receptors (VEGFR 1-3), fibroblast growth factor receptors (FGFR 1-4), platelet-derived growth factor receptors (PDGFR alpha and beta), and c-Kit. This combination is being investigated by Shanghai 6th People's Hospital as a second-line or later treatment for advanced soft tissue sarcomas to improve efficacy and reduce toxicity compared to standard chemotherapy.
- Other names
- MAGNATE-S regimen
02
Targets
DNA polymerase familyRNR (Ribonucleotide reductase)FGFR (FGFR family)KIT (c-KIT proto-oncogene receptor tyrosine kinase)TUBB (Tubulin (alpha and beta subunits))VEGFR-1 (Vascular endothelial growth factor receptor 1)VEGFR3 (Vascular endothelial growth factor receptor 3)PDGFRA (Platelet-derived growth factor receptor alpha)VEGFR2 (Vascular endothelial growth factor receptor 2)RET (Rearranged during transfection receptor tyrosine kinase)
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