Drug intelligence / Profile preview

pamiparib + tamoxifen

Development stage: Unknown
Lead developer: BeiGene
Modality: Small Molecules
Administration: Oral

Overview

A combination therapy consisting of pamiparib (BGB-290), a PARP1/2 inhibitor, and tamoxifen, a selective estrogen receptor modulator. This combination is being investigated for the treatment of ovarian cancer patients with biochemical recurrence during first-line PARP inhibitor maintenance therapy.

Targets

ESR1 (ERα)PARP2 (Poly (adp-ribose) polymerase 2)ESR2 (ERβ)

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