Drug intelligence / Profile preview

pancreatin + aspergillus oryzae enzymes

Development stage
Unknown
Lead developer
American Regent
Modality
Recombinant Proteins and Enzymes
Administration
Oral
01

Overview

A combination digestive enzyme preparation containing pancreatin and enzymes derived from the fungus *Aspergillus oryzae*. It is designed to facilitate digestion across a wide pH range by utilizing the different optimal pH environments of its components. The *Aspergillus oryzae* component, which contains cellulase, protease, and amylase, is active in the acidic environment of the stomach. The pancreatin component, containing lipase, amylase, and protease, is typically enteric-coated to ensure release in the alkaline environment of the small intestine. This dual-action formulation is primarily indicated for the treatment of dyspepsia, pancreatic exocrine insufficiency, and digestive symptoms associated with chronic pancreatitis, biliary tract disease, or post-operative digestive disorders.

Brand names
Combizym米曲菌胰酶片
Other names
Aspergillus oryzae enzymes and pancreatinCombizym Forte
02

Targets

CellulasePNLIP (Pancreatic triacylglycerol lipase)AMY (Pancreatic alpha-amylase)

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