pancrelipase (Janssen Pharmaceutical)

Pancrelipase is a highly purified mixture of pancreatic enzymes—**lipase**, **amylase**, and **protease**—extracted from porcine pancreatic glands. It acts as a **digestive enzyme replacement therapy** for patients with exocrine pancreatic insufficiency, aiding in the breakdown of dietary fats, proteins, and carbohydrates to improve absorption and nutrition. The principal mechanism of action is direct enzyme supplementation, compensating for impaired pancreatic secretion due to cystic fibrosis, chronic pancreatitis, post-pancreatectomy, pancreatic cancer, or other causes. Developed and approved as a protein-based therapy, pancrelipase is available in multiple oral formulations for use in infants, children, and adults[3][6][7].

Brand names

CREONVIOKACEZenpep

Other names

porcine pancreatic enzymepancreatinpancreatinumpancreatic extract pancrelipasepancreatic proteasepancrealipase