paracetamol + amantadine hydrochloride

**Paracetamol + amantadine hydrochloride** is a fixed-dose combination drug primarily used for symptomatic relief of common cold and influenza symptoms, including fever, headache, nasal congestion, rhinorrhea, sneezing, sore throat, and limb pain, as well as for influenza prevention and treatment. Paracetamol (acetaminophen) acts as an antipyretic and analgesic by inhibiting prostaglandin synthesis. Amantadine hydrochloride is an antiviral agent that inhibits influenza A virus replication by blocking the viral M2 ion channel and also has anticholinergic and dopaminergic effects that enhance analgesia and reduce symptoms. Formulations often include additional excipients like chlorphenamine maleate (antihistamine), caffeine (central stimulant to potentiate analgesia and counter sedation), and artificial Calculus Bovis (antipyretic and anticonvulsant). Developed in China, it is available as capsules (e.g., 0.377g, containing 250mg paracetamol and 100mg amantadine HCl) or tablets, administered orally.[1][3][5][9][10]

Brand names

Fufang Anfenwanan capsules

Other names

compound paracetamol and amantadine hydrochloride capsulescompound paracetamol and amantadine hydrochloride tabletsParacetamol and Amantadine Compound