Paracetamol + codeine

Paracetamol + codeine is a fixed-dose combination analgesic containing paracetamol (also known as acetaminophen) and the opioid analgesic codeine phosphate. It is used for the relief of mild to moderate pain when treatment with paracetamol or non-steroidal anti-inflammatory drugs alone is insufficient[5][8]. Paracetamol acts centrally to inhibit prostaglandin synthesis, reducing pain and fever, while codeine acts on the central nervous system as a weak opioid agonist at mu-opioid receptors, providing additional analgesia[1][3][5]. The combination offers greater pain relief than either agent alone, particularly in postoperative settings[8]. Prolonged use of codeine can lead to dependence; paracetamol overdose can cause severe liver damage[2][3].

Brand names

Tylenol with CodeineTylenol with Codeine No. 3Tylenol with Codeine No. 4APAP w/CodeineCapital w/CodeinePyregesic-CVopacpms-Acetaminophen with CodeineTeva-EMTEC-30Teva-EMTEC30Teva-EMTEC 30Teva-Lenoltec No. 4Triatec-30Triatec30Triatec 30

Other names

acetaminophen and codeine