Paracetamol + Dimethindene maleate + Phenylephrine hydrochloride

This drug is a fixed-dose combination of three active ingredients commonly used in over-the-counter cold and flu remedies: - **Paracetamol (acetaminophen)** is an analgesic and antipyretic that reduces pain and fever by inhibiting prostaglandin synthesis in the central nervous system. - **Dimethindene maleate** is a first-generation selective H1 antihistamine that acts as an antagonist at histamine H1 receptors, reducing symptoms such as sneezing, itching, watery eyes, and runny nose. - **Phenylephrine hydrochloride** is a sympathomimetic decongestant that stimulates alpha-1 adrenergic receptors to constrict blood vessels in the nasal mucosa, thereby reducing swelling and congestion[3][4][5]. The primary indication for this combination is symptomatic relief of common cold or influenza-like illnesses—specifically targeting headache, fever, nasal congestion, sneezing, rhinorrhea (runny nose), sore throat, muscle aches, and related symptoms[1][2]. This product has been evaluated in clinical trials for efficacy and safety as an over-the-counter remedy for these conditions[1][2].

Brand names

Vibrocil

Other names

acetaminophen + dimethindene maleate + phenylephrine hydrochloride