paracetamol + ibuprofen + doxylamine

Paracetamol + ibuprofen + doxylamine is a fixed-dose triple-combination oral product developed by V.S. Pharma (V.S. International) for over-the-counter (OTC) indications. This small molecule combination is designed to provide synergistic relief for pain and fever while addressing associated sleep disturbances or cold and flu symptoms. The formulation combines two analgesics with distinct but complementary mechanisms: paracetamol, which provides antipyretic and analgesic effects likely through central cyclooxygenase inhibition and modulation of the endocannabinoid system, and ibuprofen, a non-steroidal anti-inflammatory drug (NSAID) that non-selectively inhibits cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzymes to reduce prostaglandin synthesis. The third component, doxylamine, is a first-generation antihistamine that acts as a competitive antagonist at the H1 receptor, providing sedative properties that assist patients in sleeping through discomfort.

Other names

acetaminophen + ibuprofen + doxylamineparacetamol + ibuprofen + doxylamine succinate