paracetamol + ketorolac + granisetron

This combination is a multi-modal analgesic and antiemetic regimen consisting of paracetamol (acetaminophen), ketorolac, and granisetron. It is primarily used for perioperative pain management and the prevention of postoperative nausea and vomiting (PONV). Paracetamol and ketorolac provide synergistic non-opioid analgesia by inhibiting cyclooxygenase (COX) enzymes, thereby reducing the synthesis of pro-inflammatory prostaglandins. Granisetron is a selective 5-HT3 receptor antagonist that blocks serotonin-mediated emetic signals in the central and peripheral nervous systems. This specific regimen was utilized as a standardized baseline analgesia protocol in clinical research conducted by Ain Shams University, particularly in studies evaluating the efficacy of regional anesthesia techniques like the Serratus Posterior Superior Intercostal Plane Block (SPSIPB) for breast cancer surgery.

Other names

paracetamol + ketorolac + granisetronAnalgesia mangement group A,BAcetaminophen + Ketorolac + Granisetron