paracetamol + metoclopramide

Paracetamol + metoclopramide is a fixed-dose oral combination medication used primarily for the treatment of migraine attacks. Paracetamol acts as an analgesic and antipyretic, providing pain relief by inhibiting prostaglandin synthesis in the central nervous system. Metoclopramide is a dopamine D2 receptor antagonist with antiemetic and prokinetic properties; it alleviates nausea and vomiting associated with migraines by blocking dopamine receptors in the chemoreceptor trigger zone (CTZ) of the brain, antagonizing serotonin 5-HT3 receptors, agonizing serotonin 5-HT4 receptors, and enhancing gastric motility. The combination not only relieves headache but also addresses delayed gastric emptying often seen during migraine attacks, potentially improving absorption of paracetamol[1][2][4][5].

Brand names

ParamaxMigraeflux MCPMeteclomaxAnagrainePRIMADOL

Other names

paracetamol/metoclopramide hydrochloride