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paracetamol + morphine + ketoprofen + ketamine
- Development stage
- Phase 4
- Lead developer
- Assistance publique - Hôpitaux de Paris
- Modality
- Small Molecules
- Administration
- Intravenous
01
Overview
paracetamol + morphine + ketoprofen + ketamine is a multimodal analgesic combination regimen being evaluated for the management of acute pain during vaso-occlusive crises (VOC) in adult patients with sickle cell disease. This combination is studied as Group 08 in the PAMAVOC adaptive platform trial (NCT07826988), sponsored by Assistance Publique - Hôpitaux de Paris. The regimen combines paracetamol (acetaminophen), patient-controlled analgesia (PCA) morphine, and ketoprofen, with the potential addition of low-dose ketamine as an off-label co-analgesic for hyperalgic crises. By targeting multiple pain pathways—including cyclooxygenase inhibition, mu-opioid receptor activation, and NMDA receptor antagonism—the multimodal approach aims to optimize pain control while reducing overall opioid consumption and its associated adverse effects.
- Other names
- paracetamol + morphine + ketoprofen + ketamine
02
Targets
DOR (Opioid Receptor Delta 1)KOR (Kappa opioid receptor)MOR (Mu opioid receptor)PGHS-1 (Prostaglandin G/H Synthase 1)NMDAR (Glutamate receptor ionotropic, NMDA)
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