Drug intelligence / Profile preview

Paracetamol + orphenadrine

Development stage
Unknown
Lead developer
Pfizer
Modality
Small Molecules
Administration
Oral
01

Overview

Paracetamol + orphenadrine is a fixed-dose combination medication used primarily for the relief of acute musculoskeletal pain and muscle spasms. Paracetamol (also known as acetaminophen) acts as an analgesic and antipyretic by inhibiting prostaglandin synthesis in the central nervous system, thereby reducing pain and fever. Orphenadrine is a centrally acting muscle relaxant with anticholinergic properties; it works by blocking muscarinic receptors in the central nervous system to reduce muscle spasms and associated discomfort. The combination is commonly prescribed for conditions such as strains, sprains, tension headaches, and other painful musculoskeletal disorders[1][4][5][8].

Brand names
ANAREXCAMGESICCETAGESICCORILAX PINK
Other names
Acetaminophen + orphenadrine
02

Targets

HRH1 (Histamine H1 Receptor)NMDAR (Glutamate receptor ionotropic, NMDA)mAChR (Muscarinic acetylcholine receptors)SCN11A (NaV1.9)

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