Drug intelligence / Profile preview

paracetamol + pheniramine maleate + ascorbic acid

Development stage
Unknown
Lead developer
UPSA
Modality
Small Molecules
Administration
Oral
01

Overview

This drug is a fixed-dose **combination medication** containing **paracetamol (acetaminophen)**, **pheniramine maleate**, and **ascorbic acid (vitamin C)**. - **Paracetamol** is an analgesic and antipyretic that works primarily by inhibiting prostaglandin synthesis within the central nervous system, leading to pain relief and reduction of fever. - **Pheniramine maleate** is a first-generation antihistamine (histamine H1 receptor antagonist) that provides antiallergic, anti-inflammatory, and decongestant effects by blocking the action of histamine on H1 receptors, reducing symptoms like sneezing, runny nose, nasal congestion, lacrimation, and itching[5][6][7][13]. - **Ascorbic acid** (vitamin C) is an essential nutrient and antioxidant that helps cover increased metabolic needs during infections and supports immune function. This combination is primarily used for the **symptomatic treatment of influenza, colds, upper respiratory tract infections, allergic rhinitis, and nasopharyngitis**, relieving symptoms like fever, headache, body aches, nasal congestion, runny nose, and sneezing. The drug is commonly available as a powder for oral solution or granules, to be dissolved in water before administration[3][5][7][13].

Brand names
FervefluGripoflex 500Gripoflex500Gripoflex-500FervexCuraflu
Other names
paracetamol + ascorbic acid + pheniramine maleateacetaminophen + pheniramine maleate + ascorbic acid
02

Targets

PTGS2 (Prostaglandin-Endoperoxide Synthase 2)PGHS-1 (Prostaglandin G/H Synthase 1)HRH1 (Histamine H1 Receptor)

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