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paracetamol + phenylephrine + ascorbic acid
- Development stage
- Phase 4
- Lead developer
- Kusum Healthcare
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
A fixed-dose **combination drug** containing paracetamol, phenylephrine hydrochloride, and ascorbic acid, mainly used for the symptomatic treatment of acute respiratory infections, including cold and influenza-like syndromes. - **Paracetamol** is an analgesic and antipyretic that works primarily through **inhibition of prostaglandin synthesis in the central nervous system**, reducing fever and relieving pain[3][4][5]. - **Phenylephrine** is a sympathomimetic agent (direct alpha-adrenergic agonist) that produces **vasoconstriction**, reducing swelling of the nasal mucosa and relieving nasal congestion[3][4][5]. - **Ascorbic acid** (Vitamin C) is included to compensate for potential depletion during viral infections, acts as an antioxidant, and may support increased resistance to infection[3][4][5]. The combination is administered orally, mainly as granules or powder to be dissolved in water.
- Brand names
- Gripgo Hotmix
- Other names
- paracetamol + phenylephrine + ascorbic acid
02
Targets
ADRA1A (α1A)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)SLC23A1 (Solute carrier family 23 member 1)
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