paracetamol + pseudoephedrine

Paracetamol + pseudoephedrine is a fixed-dose combination of two active ingredients commonly used to relieve symptoms associated with upper respiratory tract infections, such as headache, fever, body aches, nasal congestion, and sinus pressure. Paracetamol (also known as acetaminophen) acts as an analgesic and antipyretic by inhibiting prostaglandin synthesis in the central nervous system. Pseudoephedrine is a sympathomimetic amine that acts primarily as an agonist at alpha adrenergic receptors in the nasal mucosa, causing vasoconstriction which reduces swelling and congestion. The combination provides both pain relief/fever reduction from paracetamol and decongestant effects from pseudoephedrine[1][5]. It is widely available under various brand names for over-the-counter use in cold, flu, or allergy-related conditions.

Brand names

Allerest No DrowsinessNexafed Sinus Pressure + PainOrnexAlka-Seltzer Cold and SinusBayer Select DecongestantCold and Flu Day (Cipla)Cold and Flu Relief Day/Night (Apohealth)Cold and Flu Day/Night (Cipla)

Other names

acetaminophen + pseudoephedrine